MMRV (Measles, Mumps, Rubella and Varicella) "PROQUAD" is made by the vaccine manufacturer Merck. This vaccine is intended for ages 12 months. - 12 years of age (2 doses is recommended) Initial U.S approval: 2005


1. Measles: fever, cough, runny nose, and red, watery eyes, commonly followed by a rash that covers the whole body

2. Mumps: fever, headache, muscle aches, tiredness, loss of appetite, swollen/tender salivary glands under the ears on one or both sides

3. Rubella: fever, sore throat, rash, headache, and eye irritation

4. Varicella (Chickenpox): an itchy rash that usually lasts about a week, in addition to fever, tiredness, loss of appetite, and headache


1. Measles, Mumps and Rubella - Respiratory Droplets, Poor Hygiene

2. Varicella - Skin to Skin Contact of Open Lesion


1. Measles Virus, Mumps Virus, Rubella Virus and Varicella Virus - (ALL LIVE VIRUSES)

2. Sucrose - (CANE or BEET SUGAR)

3. Hydrolyzed Gelatin - (COLLAGEN skin, bone, tissue of cattle, chicken, pigs, fish)

4. Sodium chloride - (SALT)

5. Sorbitol - (SUGAR ALCOHOL)

6. Monosodium L-Glutamate - (SODIUM SALT)

7. Sodium Phosphate Dibasic - (INORGANIC SALT)

8. Human Albumin - (HUMAN BLOOD)

9. Sodium Bicarbonate - (BAKING SODA)


11. Potassium Chloride - (SALT)

12. MRC-5 Diploid Fibroblasts including DNA and protein - (ABORTED KIDNEY CELLS FROM 1960's)

13. Neomycin - (ANTIBIOTIC)

14. Bovine Calf Serum - (COW BLOOD)

15. Other Buffer and Media Ingredients 


1. Any severe, life-threatening allergies

2. A weakened immune system due to disease or medical treatments (e.g.: radiation or chemotherapy, cancer)

3. A history of seizures, or has a parent, brother, or sister with a history of seizures

4. A parent, brother, or sister with a history of immune system problems

5. A condition that makes them bruise or bleed easily

6. Pregnant or might become pregnant

7. Taking salicylates (such as aspirin)

8. Recently had a blood transfusion or received other blood products

9. Have Tuberculosis

10. Had had any other vaccines in the past 4 week

11. Not feeling well


1. History of anaphylactic reaction to neomycin

2. hypersensitivity to gelatin or any other component of the vaccine

3. Primary or acquired immunodeficiency states

4. Family history of congenital or hereditary immunodeficiency

5. Immunosuppressive therapy

6. Active untreated tuberculosis or febrile illness

7. Pregnancy: Do not administer ProQuad to females who are pregnant. Pregnancy should be avoided for 3 months following vaccination with ProQuad. Increased rates of spontaneous abortion, stillbirth, congenital defects, and prematurity have been observed subsequent to infection with wild-type measles during pregnancy.

8. Population 65 years or older 


1. ProQuad (dose 1) 12 - 23 mo. old associated with higher rates of fever and febrile seizures 5 - 12 days after vaccine

2. Use CAUTION when administering ProQuad to children with a history of:

A. Cerebral Injury B. Seizures C. Any other condition in which stress due to fever should be avoided D. Anaphylaxis E. Hypersensitivity to eggs

F. Hypersensitivity to neomycin (aminoglycoside antibiotic) G. History of Thrombocytopenia (low blood platelets)

3. Defer vaccination 3 mo. or more following blood or plasma transfusions, or administration of immune globulins

4. Avoid pregnancy for 3 months following vaccination with measles, mumps, rubella, and/or varicella vaccines.

5. Vaccine recipients should attempt to avoid individuals susceptible to varicella for up to 6 weeks following vaccination. Excretion occurred in the majority of individuals 7 to 28 days after vaccination (THIS VACCINE SHEDS!)

6. Risk of Transmission of Creutzfeldt-Jakob Disease and Other Adventitious Agents. This product contains albumin, a derivative of human blood.

7. Avoid the use of salicylates (aspirin) or salicylate-containing products in children 12 mo. - 12 yrs. for 6 weeks following vaccination due to the association of Reye syndrome with aspirin therapy and wild-type varicella infection

8. It is NOT known whether varicella, measles, or mumps vaccine virus is excreted in human milk

9. Do NOT administer ProQuad to infants younger than 12 months of age or to children 13 years and older

10. Geriatric Use ProQuad is NOT indicated for use in the geriatric (elderly) population 65 or older.

11. ProQuad has not been evaluated for its carcinogenic (CANCER), mutagenic (DNA MUTATION), or Teratogenic Potential (ABNORMALITIES of PHYSIOLOGICAL DEVELOPMENT) or its potential to impair fertility (INFERTILITY)

12. Formal studies to evaluate the clinical efficacy of ProQuad have not been performed.


1. Tuberculin testing (TB test) should be administered anytime before, simultaneously with, or at least 4 to 6 weeks after ProQuad.